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Atvast (Brand name: Atorlip-5)

  • $0.59AUD
  • Availability: In Stock
  • Active Ingredient Atorvastatin
Atvast is used to treat high cholesterol.
Analogs of Atvast (Brand name: Atorlip-5): Atorlip-10   Atorlip-20   Lipitor  
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5 mg
Product name Per Pill Per Pack  
60 pills $0.95AUD $57.25AUD
90 pills $0.81AUD $85.88AUD $72.83AUD
120 pills $0.74AUD $114.50AUD $88.39AUD
180 pills $0.66AUD $171.75AUD $119.53AUD
270 pills $0.62AUD $257.63AUD $166.25AUD
360 pills $0.59AUD $343.50AUD $212.97AUD

INDICATIONS

Atvast is used to treat high cholesterol. Atvast is also used to lower the risk of stroke, heart attack, or other heart complications in people with coronary heart disease or type 2 diabetes. Atvast is a cholesterol-lowering medication that blocks the production of cholesterol (a type of fat) in the body. Atvast reduces low-density lipoprotein (LDL) cholesterol and total cholesterol in the blood. Lowering your cholesterol can help prevent heart disease and hardening of the arteries, conditions that can lead to heart attack, stroke, and vascular disease.

INSTRUCTIONS

Use Atvast as directed by your doctor.

  • Take Atvast by mouth with or without food.
  • Eating grapefruit or drinking grapefruit juice may increase the amount of Atvast in your blood, which may increase your risk for serious side effects. The risk may be greater with large amounts of grapefruit or grapefruit juice. Avoid large amounts of grapefruit or grapefruit juice (eg, more than one quart daily). Talk with your doctor or pharmacist if you have questions about including grapefruit or grapefruit juice in your diet while you are taking Atvast.
  • Continue to take Atvast even if you feel well. Do not miss any doses.
  • If you miss a dose of Atvast, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Atvast.

STORAGE

Store Atvast at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Atvast out of the reach of children and away from pets.

MORE INFO:

Active Ingredient: Atorvastatin Calcium.

SAFETY INFORMATION

Do NOT use Atvast if:

  • you are allergic to any ingredient in Atvast
  • you have liver problems or unexplained abnormal liver function tests
  • you are pregnant or breast-feeding
  • you are taking an HIV protease inhibitor (eg, ritonavir), itraconazole, or mibefradil.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Atvast. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have low blood pressure, a serious infection, or a history of seizures
  • if you have metabolism, hormonal, or electrolyte problems
  • if you drink alcohol or have a history of liver problems or alcohol abuse
  • if you have recently had major surgery, a serious injury, or a stroke.

Some medicines may interact with Atvast. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Amiodarone, azole antifungals (eg, itraconazole, ketoconazole), colchicine, diltiazem, fibrates (eg, clofibrate, gemfibrozil), fluconazole, HIV protease inhibitors (eg, ritonavir), imatinib, immunosuppressants (eg, cyclosporine), macrolides (eg, erythromycin), mibefradil, nefazodone, niacin, non-nucleoside reverse transcriptase inhibitors (eg, delavirdine), streptogramins (eg, dalfopristin), telithromycin, vasopressin receptor antagonists (eg, conivaptan), verapamil, or voriconazole because they may increase the risk of muscle or kidney problems
  • Bosentan, carbamazepine, efavirenz, rifampin, or St. John's wort because they may decrease Atvast's effectiveness
  • Digoxin, hormonal contraceptives (eg, birth control pills), macrolide immunosuppressants (eg, tacrolimus), or spironolactone because the risk of their side effects may be increased by Atvast.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Atvast may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

  • Atvast may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Atvast with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.
  • Drinking alcohol daily or in large amounts may increase the risk of liver problems with Atvast. Check with your doctor before drinking alcohol while you are taking Atvast.
  • Follow the diet and exercise program given to you by your health care provider.
  • Tell your doctor or dentist that you take Atvast before you receive any medical or dental care, emergency care, or surgery.
  • Women should use effective birth control while taking Atvast. Check with your doctor if you have questions about using birth control.
  • Report any unexplained muscle pain, tenderness, or weakness to your doctor right away, especially if you also have a fever or general body discomfort.
  • Lab tests, including blood cholesterol levels and liver function tests, may be performed while you use Atvast. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Atvast should be used with extreme caution in children younger than 10 years old and in those who have not reached puberty; safety and effectiveness in these children have not been confirmed.
  • Pregnancy and breast-feeding: Do not use Atvast if you are pregnant. It may cause harm to the fetus. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. It is not known if Atvast is found in breast milk. Do not breastfeed while taking Atvast.

SIDE EFFECTS

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Constipation; gas; headache; stomach pain or upset; weakness.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bone, joint, or tendon pain; change in the amount of urine produced; chest pain; dark urine; fever, chills, or persistent sore throat; flu-like symptoms; joint pain; muscle pain, tenderness, or weakness (with or without fever or fatigue); painful or frequent urination; pale stools; red, swollen, blistered, or peeling skin; severe stomach pain; swelling of the hands, ankles, or feet; yellowing of the eyes or skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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Following the safety recommendations and taking into consideration contraindications, warnings and precautions will decrease the risk of experiencing unwanted reactions and side effects. However, patients, who are hypersensitive to the components of the drug, can witness mild to severe adverse reactions listed below. Contact your doctor or online medical specialist to eliminate the risk of serious consequences. Seek medical assistance the moment you have noticed the following side effects:

More Common

  • Headache
  • hoarseness
  • lower back or side pain
  • pain or tenderness around the eyes and cheekbones
  • painful or difficult urination
  • stuffy or runny nose

Less Common

  • Abdominal or stomach pain
  • back pain
  • belching or excessive gas
  • constipation
  • general feeling of discomfort or illness
  • heartburn, indigestion, or stomach discomfort
  • lack or loss of strength
  • loss of appetite
  • nausea
  • shivering
  • sweating
  • trouble sleeping
  • vomiting

Incidence Not Known

  • Blistering, peeling, or loosening of the skin
  • chills
  • dark-colored urine
  • diarrhea
  • joint pain
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • red skin lesions, often with a purple center sore
  • red, irritated eyes
  • sore throat
  • sores, ulcers, or white spots in the mouth or on the lips
  • Appetite increased
  • black, tarry stools
  • bloody nose
  • bloody or cloudy urine
  • blurred vision
  • continuing ringing or buzzing or other unexplained noise in the ears
  • difficult, burning, or painful urination
  • difficulty seeing at night
  • excessive muscle tone or tension
  • fruit-like breath odor
  • groin or scrotum pain
  • inability to have or keep an erection
  • increased body movements
  • increased sensitivity of the eyes to light
  • increased sensitivity to touch or pain
  • increased thirst
  • increased urination
  • loss of bladder control
  • loss of sexual ability, drive, or desire
  • menstrual bleeding occurring earlier or lasting longer than usual
  • mental depression
  • nervousness
  • nightmares
  • pale skin
  • paranoia
  • pinpoint red spots on the skin
  • slurred speech
  • swollen or tender lymph glands in the neck, armpit, or groin
  • unable to move or feel face
  • unusual bleeding or bruising
  • weight loss
Type Small Molecule
Accession Number DB01076  (APRD00055)
Groups Approved
Synonyms
  • atorvastatina
  • atorvastatine
  • atorvastatinum
UNII A0JWA85V8F
CAS number 134523-00-5
Weight Average: 558.6398
Monoisotopic: 558.253000445
Chemical Formula C33H35FN2O5
InChI
InChI=1S/C33H35FN2O5/c1-21(2)31-30(33(41)35-25-11-7-4-8-12-25)29(22-9-5-3-6-10-22)32(23-13-15-24(34)16-14-23)36(31)18-17-26(37)19-27(38)20-28(39)40/h3-16,21,26-27,37-38H,17-20H2,1-2H3,(H,35,41)(H,39,40)/t26-,27-/m1/s1
IUPAC Name
(3R,5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-(propan-2-yl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid
Protein binding

>98% bound to plasma proteins

Toxicity

Generally well-tolerated. Side effects may include myalgia, constipation, asthenia, abdominal pain, and nausea. Other possible side effects include myotoxicity (myopathy, myositis, rhabdomyolysis) and hepatotoxicity. To avoid toxicity in Asian patients, lower doses should be considered.

Half life

14 hours, but half-life of HMG-CoA inhibitor activity is 20-30 hours due to longer-lived active metabolites

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  • Sydney
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  • Grafton
  • Lithgow
  • Liverpool
  • Newcastle
  • Orange
  • Parramatta
  • Penrith
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  • Wagga Wagga
  • Wollongong