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Torsemide

  • $0.46AUD
  • Availability: In Stock
  • Active Ingredient torsemide
Torsemide is used for treatment of edema (swelling) associated with heart, kidney, or liver failure, or conditions when there is excess of body water.

20 mg
Product name Per Pill Per Pack  
30 pills $1.52AUD $45.62AUD
60 pills $1.19AUD $91.25AUD $71.34AUD
90 pills $1.08AUD $136.87AUD $97.05AUD
120 pills $1.02AUD $182.49AUD $122.76AUD
180 pills $0.97AUD $273.74AUD $174.21AUD
270 pills $0.93AUD $410.61AUD $251.36AUD
360 pills $0.91AUD $547.48AUD $328.49AUD
10 mg
Product name Per Pill Per Pack  
60 pills $0.82AUD $49.18AUD
90 pills $0.68AUD $73.76AUD $60.79AUD
120 pills $0.60AUD $98.35AUD $72.40AUD
180 pills $0.53AUD $147.53AUD $95.60AUD
270 pills $0.48AUD $221.29AUD $130.42AUD
360 pills $0.46AUD $295.05AUD $165.24AUD

Drug Uses

Torsemide is used for treatment of edema (swelling) associated with heart, kidney, or liver failure, or conditions when there is excess of body water. It is also used alone or with other medicines to treat high blood pressure.

It may also be used to treat certain conditions as determined by your doctor, which may not be listed in the professional package insert.

How to use

Use Torsemide as directed by your doctor.

Take Torsemide by mouth with or without food.
Torsemide may increase the amount of urine or cause you to urinate more often when you first start taking it. To keep this from disturbing your sleep, try to take your dose before 6 pm.
If you also take cholestyramine, do not take it within 4 hours before or after taking Torsemide . Check with your doctor if you have questions.
Avoid eating licorice or Korean ginseng while taking Torsemide.
Ask your health care provider any questions you may have about how to use Torsemide.

Drug Class and Mechanism

Torsemide is a loop diuretic. It works by making the kidney eliminate larger amounts of electrolytes (especially sodium and potassium salts) and water than normal (diuretic effect).

Missed Dose

If you miss a dose of Torsemide and are using it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Storage

Store Torsemide between 68 and 77 degrees F (20 and 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Torsemide out of the reach of children and away from pets.

Warnings/Precautions

Do not use Torsemide if:

you are allergic to any ingredient in Torsemide or to sulfonylureas (e.g., glyburide);
you are unable to urinate.
Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Torsemide . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
if you are pregnant, planning to become pregnant, or are breast-feeding
if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
if you have allergies to medicines or other substances
if you have fluid in your abdomen, hearing impairment, diabetes mellitus, low urine output, high blood uric acid levels, a blood disorder, kidney disease, lupus, had a heart attack, are dehydrated, or have liver disease or heart failure

Some MEDICINES MAY INTERACT with Torsemide . Tell your health care provider if you are taking any other medicines, especially any of the following:
Aminoglycosides (eg, gentamicin) or cisplatin because the risk of temporary or permanent hearing loss may be increased
Nonsteroidal anti-inflammatory drugs (NSAIDs; eg, ibuprofen, naproxen) or probenecid because they may decrease the effectiveness of Torsemide
Chloral hydrate, digitalis (eg, digoxin), lithium, suramin because side effects may be increased by Torsemide
Nondepolarizing muscle relaxants (eg, pancuronium) because its actions and side effects may be increased or decreased by Torsemide

Possible Side Effects

Check with your doctor if any of these most common side effects persist or become bothersome:

constipation; dizziness or lightheadedness when sitting up or standing; excessive urination; headache; increased coughing; nasal inflammation; nausea.

Seek medical attention right away if any of these severe side effects occur:
severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; diarrhea; dry mouth or unusual thirst; hearing loss or ringing in the ears; loss of appetite; muscle pain or cramps; rapid or irregular heartbeat; rectal bleeding; restlessness; unusual tiredness or weakness; vomiting.

More Information

If you have any questions about Torsemide, please talk with your doctor, pharmacist, or other health care provider.

Torsemide is to be used only by the patient for whom it is prescribed. Do not share it with other people.

If your symptoms do not improve or if they become worse, check with your doctor.

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Type Small Molecule
Accession Number DB00214  (APRD00295, APRD00217)
Groups Approved
Synonyms
  • 1-Isopropyl-3-((4-m-toluidino-3-pyridyl)sulfonyl)urea
  • Luprac
  • N-(((1-Methylethyl)amino)carbonyl)-4-((3-methylphenyl)amino)-3-pyridinesulfonamide
  • Torasemida
  • Torasemidum
  • Torsemide
UNII W31X2H97FB
CAS number 56211-40-6
Weight Average: 348.42
Monoisotopic: 348.125611216
Chemical Formula C16H20N4O3S
InChI
InChI=1S/C16H20N4O3S/c1-11(2)18-16(21)20-24(22,23)15-10-17-8-7-14(15)19-13-6-4-5-12(3)9-13/h4-11H,1-3H3,(H,17,19)(H2,18,20,21)
IUPAC Name
1-({4-[(3-methylphenyl)amino]pyridin-3-yl}sulfonyl)-3-(propan-2-yl)urea
Protein binding

> 99%

Toxicity

Symptoms of overdose include dehydration, hypovolemia, hypotension, hyponatremia, hypokalemia, hypochloremic alkalosis, and hemoconcentration. Oral LD50 in rat is 5 g/kg, and intravenous LD50 in rat is 500 mg/kg.

Half life

3.5 hours

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