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Clozaril

  • $0.37AUD
  • Availability: In Stock
  • Active Ingredient Clozapine
Clozaril is an atypical antipsycotic. It is used to treat schizophrenia in patients who do not respond to other medicines.
Other names of Clozaril: a   b   c   d   e   f   g   h   i   j   k   l   m   n   o   p   q   r   s   t   u   v   w   x   y   z  
Azaleptinum   Alemoxan   Alemoxan   Apo-Clozapine   Aspen Clozapine   Azaleptine   Azaleptol-GU  
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50 mg
Product name Per Pill Per Pack  
60 pills $0.79AUD $47.37AUD
90 pills $0.67AUD $71.05AUD $60.25AUD
120 pills $0.61AUD $94.74AUD $73.14AUD
180 pills $0.55AUD $142.11AUD $98.90AUD
270 pills $0.51AUD $213.16AUD $137.56AUD
360 pills $0.49AUD $284.21AUD $176.22AUD
25 mg
Product name Per Pill Per Pack  
90 pills $0.52AUD $46.50AUD
180 pills $0.42AUD $93.00AUD $75.01AUD
270 pills $0.38AUD $139.49AUD $103.52AUD
360 pills $0.37AUD $185.99AUD $132.05AUD
100 mg
Product name Per Pill Per Pack  
60 pills $1.05AUD $63.16AUD
90 pills $0.80AUD $94.75AUD $71.62AUD
120 pills $0.67AUD $126.33AUD $80.09AUD
180 pills $0.54AUD $189.49AUD $97.01AUD
270 pills $0.45AUD $284.24AUD $122.40AUD
360 pills $0.41AUD $378.98AUD $147.79AUD

Product Description

Common use

Clozaril is an atypical antipsycotic. It is used to treat schizophrenia in patients who do not respond to other medicines. It decreases the risk of suicidal behavior. It affects certain chemicals in the brain.

Dosage and directions

Take Clozaril as prescribed by your doctor. Take it with or without food. Take with food to reduce stomach irritation if stomach upset occurs. Continue to take the medicine even if you feel well. Do not stop taking it suddenly without your doctor's advice.

Precautions

Tell your doctor about all your conditions, especially if you are pregnant or plan to become pregnant, breastfeeding, if you have any allergies, if you have a history of blood clots, blood problems, high blood cholesterol levels, heart problems, or lung or breathing problems, if you have a history of an enlarged prostate; prolonged, painful erections; liver or kidney problems; seizures (eg, epilepsy); glaucoma; stomach or bowel problems; or dementia, if you have poor health, diabetes, or a family member with diabetes, or you are very overweight, if you have decreased activity of enzymes that metabolize certain medicines.

Contraindications

You should not to take Clozaril if you have allergy to it, if you have severe drowsiness, you have uncontrolled seizures (epilepsy) or loss of bowel muscle movement (paralytic ileus), you have bone marrow problems, other blood cell problems, or a history of blood problems caused by Clozaril, you are taking other medicines that may cause blood problems.

Possible side effects

The most common side effects are dry mouth, headache, dizziness, heartburn, increased sweating or saliva production, lightheadedness when you stand up; nausea; strange dreams; trouble sleeping; weight gain.
Severe side effects include: severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); agitation; calf pain or tenderness; chest pain; confusion; dark urine; decreased coordination; fainting; fast or irregular heartbeat; fever, chills, or sore throat; increased hunger, thirst, or urination; infection; involuntary movements of the tongue, face, mouth, or jaw (tongue sticking out, puffing of cheeks, mouth puckering, chewing movements); loss of appetite; numbness of an arm or leg; rapid breathing; restlessness; seizures; severe headache, dizziness, or vomiting; severe or persistent nausea or constipation; severe stomach pain; shortness of breath; stiff muscles; sudden, unusual weight gain; swelling of the hands, ankles, or feet; tremor; trouble swallowing; uncontrolled muscle movements; unusual mental or mood changes; unusual tiredness or weakness; vision changes; vomiting; yellowing of the skin or eyes.

Drug interaction

Tell your doctor about all medicines you are taking and especially: benzodiazepines (lorazepam) or other medicines for mental or mood problems because the risk of heart or breathing problems may be increased; cimetidine, erythromycin, quinolone antibiotics (ciprofloxacin), risperidone, or selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine) because they may increase the risk of Clozaril's side effects; barbiturates (phenobarbital), hydantoins (phenytoin), nicotine, or rifampin because they may decrease Clozaril's effectiveness ; antiarrhythmics (eg, propafenone, quinidine), anticholinergics (benztropine), carbamazepine, debrisoquin, dextromethorphan, medicines for depression or high blood pressure, phenothiazines (chlorpromazine), or tricyclic antidepressants (amitriptyline) because the risk of their side effects may be increased by Clozaril.

Missed dose

If you miss a dose of Clozaril, take it as soon as possible. If it is almost time for your next dose, skip the missed dose. Go back to your regular dosing schedule. Do not take 2 doses at once. If you miss taking a dose of Clozaril for more than 2 days do not start taking it again. Contact your doctor right away for instructions.

Overdose

Symptoms of overdose are drowsiness, slow or difficult breathing, dizziness, excessive salvation, fainting, coma, fast ot irregular heartbeats. If you suspect overdose seek medical attention immediately.

Storage

Store Clozaril at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Clozaril out of the reach of children and away from pets.

Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information on the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

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Following the safety recommendations and taking into consideration contraindications, warnings and precautions will decrease the risk of experiencing unwanted reactions and side effects. However, patients, who are hypersensitive to the components of the drug, can witness mild to severe adverse reactions listed below. Contact your doctor or online medical specialist to eliminate the risk of serious consequences. Seek medical assistance the moment you have noticed the following side effects:

Rare

  • Absence of or decrease in movement
  • change in appetite
  • dark urine
  • decreased sexual ability
  • difficult or fast breathing or sudden shortness of breath
  • increased sweating
  • increased thirst
  • increased urination
  • lip smacking or puckering
  • muscle stiffness (severe)
  • nausea
  • puffing of the cheeks
  • rapid or worm-like movements of the tongue
  • swelling or pain in the leg
  • uncontrolled chewing movements
  • uncontrolled movements of the arms and legs
  • unusual bleeding or bruising
  • unusually pale skin
  • vomiting
  • weakness
  • yellow eyes or skin

More Common

  • Blurred vision
  • confusion
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fainting
  • fast, pounding, or irregular heartbeat or pulse
  • fever
  • shakiness in the legs, arms, hands, or feet
  • sleepiness or unusual drowsiness
  • sweating
  • trembling or shaking of the hands or feet
  • unusual tiredness or weakness
  • Acid or sour stomach
  • belching
  • feeling of constant movement of self or surroundings
  • heartburn
  • relaxed and calm sensation of spinning
  • sleepiness

Less Common

  • Anxiety
  • black, tarry stools
  • chest pain
  • chills
  • convulsions
  • cough or hoarseness
  • decrease in the frequency of urination
  • decrease in urine volume
  • difficult or labored breathing
  • difficulty in passing urine (dribbling)
  • discouragement
  • dry mouth
  • feeling sad or empty
  • fever with or without chills
  • frequent strong or increased urge to urinate
  • general feeling of tiredness or weakness
  • headache
  • hyperventilation
  • irritability
  • lack of appetite
  • loss of bladder control
  • loss of interest or pleasure
  • lower back or side pain
  • muscle spasm or jerking of the arms or legs
  • painful or difficult urination
  • pounding in the ears
  • restlessness or need to keep moving
  • severe or continuing headache
  • shakiness and unsteady walk
  • slurred speech
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • sudden jerky movements of the body
  • sudden loss of consciousness
  • swollen glands
  • throat discomfort
  • tightness in the chest
  • trouble concentrating
  • trouble sleeping
  • unsteadiness, trembling, or other problems with muscle control or coordination
  • Blurred or loss of vision
  • change or problem with discharge of semen
  • disturbed color perception
  • double vision
  • halos around lights
  • inability to sit still
  • increase in body movements
  • muscle ache or pain
  • muscle weakness
  • night blindness
  • nightmares
  • overbright appearance of lights
  • pain in the back, neck, or legs
  • pain in the chest below the breastbone
  • severe muscle stiffness
  • sore tongue
  • stuffy nose
  • tunnel vision
  • unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness

Incidence Not Known

  • Abdominal or stomach pain
  • bloating
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • clay-colored stools
  • confusion as to time, place, or person
  • constipation
  • diarrhea
  • epileptic seizure that will not stop
  • feeling that others are watching you or controlling your behavior
  • feeling that others can hear your thoughts
  • feeling, seeing, or hearing things that are not there
  • holding false beliefs that cannot be changed by fact
  • inability to move the eyes
  • increased blinking or spasms of the eyelid
  • indigestion
  • itching or skin rash
  • joint pain
  • light-colored stools
  • muscle twitching
  • pains in the stomach, side, or abdomen, possibly radiating to the back
  • rhythmic movement of the muscles
  • severe mood or mental changes
  • sticking out of the tongue
  • swelling around the eyes
  • swelling of the body or feet and ankles
  • trouble with speaking
  • unpleasant breath odor
  • unusual behavior
  • unusual excitement, nervousness, or restlessness
  • unusual facial expressions
  • unusual weight gain
  • upper right abdominal or stomach pain
  • vomiting of blood
  • Blistering, peeling, or loosening of the skin
  • hives
  • increased sensitivity of the skin to sunlight
  • painful or prolonged erection of the penis
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • reddening of the skin, especially around the ears
  • severe stomach pain
  • severe sunburn
  • sores, welting, or blisters
  • swelling of the eyes, face, or inside of the nose
  • swelling of the salivary glands
Type Small Molecule
Accession Number DB00363  (APRD00470)
Groups Approved
Synonyms
  • Clozapin
  • Clozapina
  • Clozapine
  • Clozapinum
UNII J60AR2IKIC
CAS number 5786-21-0
Weight Average: 326.823
Monoisotopic: 326.129824335
Chemical Formula C18H19ClN4
InChI
InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
IUPAC Name
6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatricyclo[9.4.0.0³,⁸]pentadeca-1(15),3,5,7,9,11,13-heptaene
Protein binding

97% (bound to serum proteins)

Toxicity

Clozapine carries a black-box warning for agranulocytosis.

Half life

8 hours (range 4-12 hours)

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  • Sydney
  • Albury
  • Armidale
  • Bathurst
  • Blue Mountains
  • Broken Hill
  • Campbelltown
  • Cessnock
  • Dubbo
  • Goulburn
  • Grafton
  • Lithgow
  • Liverpool
  • Newcastle
  • Orange
  • Parramatta
  • Penrith
  • Queanbeyan
  • Tamworth
  • Wagga Wagga
  • Wollongong